Delving Deeper: The Lesser Known Benefits of Lion's Mane Mushroom

Delving Deeper: The Lesser Known Benefits of Lion's Mane Mushroom

If you’ve been following us here at Keto Brainz, you’ll know that we've always been enthusiastic about the extraordinary Lion’s Mane mushroom (Hericium erinaceus). You might recall our discussions about its remarkable ability to bolster nervous system health by enhancing Nerve Growth Factor (NGF) and Brain Derived Neurotrophic Factor (BDNF). However, Lion's Mane is much more than just a cognitive enhancer.

This beautiful fungus extends its benefits to other aspects of health as well. While it is more popularly known to contribute positively to nervous system health, but it also plays a significant role in regulating blood sugar and blood pressure, improving lipid profiles, supporting liver health, and even protecting gut health. Lion’s Mane is indeed not just a one-trick pony, but a multi-faceted gem in the realm of supplementation.


Blood Sugar Regulation

Lion's Mane mushroom (Hericium erinaceus) has garnered attention for its potential in regulating blood sugar, which is crucial for managing conditions like diabetes. This regulation appears to occur through several key mechanisms. Firstly, Lion's Mane may enhance insulin sensitivity, which is vital for effective blood sugar management. Insulin is the hormone responsible for the uptake of glucose from the bloodstream into the cells, and improved sensitivity to insulin means more efficient glucose regulation.

Another significant mechanism is the inhibition of alpha-glucosidase, an enzyme involved in breaking down carbohydrates into glucose. By inhibiting this enzyme, Lion's Mane can slow the absorption of sugar into the blood, helping to prevent spikes in blood sugar levels after eating. Additionally, the mushroom’s antioxidant properties contribute to blood sugar regulation. Oxidative stress is a factor in insulin resistance and diabetic complications, and the antioxidants in Lion's Mane may help mitigate this, supporting better blood sugar control.

There are also indications that Lion's Mane positively affects pancreatic cells, which produce insulin, potentially leading to better overall glucose management. Furthermore, its anti-inflammatory properties may improve insulin sensitivity by reducing chronic inflammation, a known factor in the development of insulin resistance.


Potential Therapeutic Benefits For Diabetes

Diabetes mellitus, characterized by persistent high blood sugar levels, poses significant health challenges, often exacerbated by oxidative stress. Achieving precise control of blood glucose is a pivotal aspect of diabetes management but remains a daunting task with current medications. This complexity often necessitates the use of multiple drugs to reach desired glycemic targets. An innovative approach in diabetes treatment is dual-targeting: simultaneously managing hyperglycemia and oxidative stress. This method underscores the potential benefits of alternative therapies that specifically address oxidative stress alongside glucose control.

When it comes to alternative therapies, our pal Hericium erinaceus, stands out for its varied biological and clinical properties, particularly its antioxidant potential. The mushroom is rich in diverse bioactive components, including polysaccharides, sterols, and fatty acids. Recent studies have shed light on its various effects, such as inhibiting HIV-1 reverse transcriptase and reducing cell death due to ER (endoplasmic reticulum)-stress. These findings point towards the mushroom’s potential in enhancing the body's innate immune response and managing oxidative stress-related complications in diabetes.

A notable study compared the antidiabetic effects of AEHE (an extract from Hericium erinaceus) with glibenclamide, a standard hypoglycemic drug. The results were promising: AEHE exhibited similar blood sugar-regulating effects to glibenclamide, potentially by stimulating insulin release from pancreatic β-cells. Furthermore, AEHE treatment in diabetic rats not only reduced blood glucose levels but also led to an increase in insulin production. This suggests its possible role in stimulating pancreatic insulin production or releasing insulin from its bound form. The study also highlighted AEHE’s positive impact on body weight and lipid metabolism, indicating its role in normalizing lipid profiles through glucose and insulin regulation.

These findings paint a hopeful picture for AEHE as a complementary treatment in diabetes management. Its ability to regulate blood sugar, coupled with its antioxidant properties, positions it as a valuable addition to diabetes therapy. However, further research is essential to fully understand its mechanisms and therapeutic potential. This study opens new avenues in the search for effective and holistic treatments for diabetes, emphasizing the importance of exploring natural compounds in disease management.


Lipid Oxidation Inhibition

A study focusing on Hericium erinaceus (Lion's Mane mushroom) has uncovered significant findings in the context of atherosclerosis, a key factor in cardiovascular diseases and stroke. Atherosclerosis (the hardening of arteries) is closely linked to high levels of total cholesterol and LDL-cholesterol, with oxidized LDL (ox-LDL) playing a crucial role in its pathophysiology. The study explored the effects of various solvent partitioned fractions of Lion's Mane mushroom on ox-LDL and HMG Co-A reductase activity, a key enzyme in cholesterol biosynthesis.


The research began with the in vitro oxidation of human LDL molecules using iron ions, simulating the oxidative conditions found in atherosclerotic arteries. It was discovered that the application of different fractions of Lion's Mane mushroom significantly increased the lag time of LDL oxidation, indicating a protective effect against oxidative stress. Among these, the hexane and dichloromethane (DCM) fractions showed particular efficacy in reducing LDL cholesterol oxidation.

The study also examined the formation of malondialdehyde (MDA), a marker of lipid peroxidation during LDL oxidation. Remarkably, the hexane fraction of Lion's Mane exhibited a potent inhibitory effect on MDA formation, demonstrating strong antioxidant properties. This suggests the mushroom's potential in mitigating oxidative stress associated with atherosclerosis. 

Additionally, the study tested the impact of Lion's Mane fractions on the activity of HMG Co-A reductase. The hexane fraction was found to most effectively inhibit the enzyme, suggesting a role in cholesterol management. GC-MS analysis identified several bioactive components in this fraction, including ergosterol and linoleic acid, which are known for their anti-oxidative effects.

These findings highlight the potential of Lion's Mane mushroom, particularly its hexane fraction, as a natural agent in managing atherosclerosis. Its ability to inhibit LDL oxidation and influence cholesterol biosynthesis positions it as a promising complementary approach to conventional treatments for cardiovascular health.


Liver Health

Lion's Mane mushroom (Hericium erinaceus) has been studied for its potential liver-protective properties, showing promising results in various studies. One of the key ways Lion's Mane may protect the liver is through its potent antioxidant properties. The liver is particularly susceptible to damage from oxidative stress, which occurs when there is an imbalance between free radicals and antioxidants in the body. Lion's Mane contains several compounds with antioxidant activity that can help neutralize harmful free radicals, thereby reducing oxidative stress and preventing liver damage.

Additionally, Lion's Mane may also have anti-inflammatory effects, which are beneficial for liver health. Chronic inflammation can lead to various liver conditions, including hepatitis and cirrhosis. The anti-inflammatory compounds in Lion's Mane can help reduce inflammation in the liver, providing a protective effect. Furthermore, some studies suggest that Lion's Mane might aid in the regeneration of liver cells, which is crucial for maintaining liver function, especially after injury or exposure to toxins.

To dive a little deeper, the study Protective Effect of Hericium erinaceus on Alcohol Induced Hepatotoxicity in Mice, investigated the effects of Hericium erinaceus mushroom extract (HEM) on liver injury induced by acute alcohol consumption in an animal model. It was found that HEM supplementation significantly mitigated liver damage typically caused by acute binge drinking and ethanol toxicity. This liver damage is often evidenced by the leakage of cellular enzymes like AST (Aspartate Transaminase) and ALT (Alanine Transaminase) into the bloodstream, which are sensitive indicators of liver cell injury. The study confirmed that HEM effectively inhibited the increase in AST and ALT levels in the serum of mice treated with ethanol.

Additionally, the study focused on malondialdehyde (MDA) activity, a common indicator of liver tissue damage and oxidative stress. Oxidative stress is a critical factor in liver injury caused by acute alcohol administration. The results showed that the MDA levels were significantly higher in the ethanol group compared to the control group, indicating increased oxidative stress. However, in the HEM-treated group, MDA levels were notably lower, suggesting that HEM effectively scavenged the free radicals released in the liver, thereby reducing oxidative stress and its associated damage.

The research also examined the Total Antioxidant Status (TAOS) activity as an indirect measure of oxidative stress. Higher hepatic TAOS levels were detected in the alcohol-induced liver injury model, but these levels decreased in the HEM-treated group, indicating that HEM might mitigate ethanol toxicity by reducing oxidative stress.

Furthermore, the study explored the role of NF-κB, a key transcription factor associated with pro-inflammatory responses and alcoholic liver disease. It was found that alcohol induced the activation of NF-κB in the liver, but this activation was suppressed by HEM treatment.

Pathological changes in the liver, such as lymphocyte and neutrophil infiltration around hepatic veins, are typical indicators of ethanol-induced hepatic injury. The study observed that HEM treatment resulted in fewer of these pathological changes, indicating its potential protective effect against alcohol-induced liver damage.

In conclusion, the study suggests that HEM has hepatoprotective effects against liver damage caused by acute alcohol exposure, primarily through the inhibition of NF-kB activation and the reduction of oxidative stress markers like TAOS. This finding points to the potential of HEM as a treatment option in alcoholic liver disease.


Digestive Health

Lion's Mane mushroom (Hericium erinaceus) is increasingly recognized for its beneficial effects on gut health. One of the primary ways it supports the gut is through its potential prebiotic properties. Prebiotics are substances that promote the growth of beneficial bacteria in the gut, contributing to a healthy gut microbiome. The polysaccharides found in Lion's Mane, such as beta-glucans, are believed to serve as food for these beneficial bacteria, thereby improving gut flora balance. This balance is crucial for overall digestive health, nutrient absorption, and can even impact immune function.

Additionally, Lion's Mane has been studied for its potential to enhance the intestinal barrier function. A healthy intestinal barrier is essential in preventing the entry of harmful substances into the bloodstream, a process known as "leaky gut." Compounds in Lion's Mane may help in strengthening this barrier, thereby reducing the likelihood of inflammation and other gut-related issues. Moreover, the mushroom's anti-inflammatory properties are beneficial in managing conditions like inflammatory bowel disease (IBD), as they can help reduce gut inflammation, a common symptom in such disorders.

In the study, extracts from Hericium erinaceus relieve inflammatory bowel disease by regulating immunity and gut microbiota investigated the effects of Hericium erinaceus (HE), a traditional edible mushroom, on inflammatory bowel disease (IBD) using a rat model. Rats with IBD were induced by trinitro-benzene-sulfonic acid (TNBS) enema and then treated with various extracts of HE (polysaccharide, alcoholic, and whole extracts) for two weeks. The study observed significant improvements in the IBD rats, including reductions in damage activity, common morphous, and tissue damage index scores in the colonic mucosa. Additionally, myeloperoxidase (MPO) activities, which are indicative of inflammation, were decreased.

The study also noted changes in inflammatory factors within the colonic mucosa. There was an increase in serum cytokines, Foxp3, and interleukin (IL)-10, while NF-κB p65 and tumor necrosis factor (TNF)-α were decreased. T cells were also found to be activated, particularly in the group treated with alcoholic extracts of HE.

An important finding of the study was the significant change in the structure of gut microbiota in the HE extracts-treated groups compared to the control group. This suggests that HE extracts may positively influence gut health. Further analysis indicated that the polysaccharides in HE extracts may serve a prebiotic role, enhancing the growth of beneficial gut bacteria, while the alcoholic extracts exhibited bactericidal and immunomodulatory effects.

Overall, the study demonstrated that Hericium erinaceus extracts could potentially alleviate IBD by regulating gut microbiota and improving host immunity. This points to HE’s clinical potential in the treatment of IBD through its effects on both the gut microbiome and the immune system.


In our exploration of the lesser-known benefits of Lion's Mane mushroom, we've uncovered a range of intriguing properties beyond its famed cognitive enhancements.

This remarkable fungus has shown potential in regulating blood sugar, an attribute particularly beneficial for managing diabetes.

Its ability to enhance insulin sensitivity and inhibit enzymes responsible for breaking down carbohydrates contributes to this regulatory effect.

Additionally, Lion's Mane demonstrates liver-protective qualities, thanks to its antioxidant and anti-inflammatory compounds, which are instrumental in mitigating oxidative stress and liver cell damage.

This mushroom also plays a significant role in inhibiting lipid oxidation, a key factor in the development of atherosclerosis, by preventing the oxidation of LDL cholesterol and influencing cholesterol biosynthesis.

Lastly, its impact on gut health is noteworthy; Lion's Mane promotes a healthy gut microbiome through its prebiotic-like properties and aids in maintaining gut barrier integrity, essential for overall digestive wellness.

These multifaceted benefits of Lion's Mane highlight its potential as a natural supplement for a variety of health concerns.





Meet the Author:
David Battisti, MScN

I am a multi-sport athlete with a fascination with nutritional sciences. I was diagnosed with severe chronic asthma at the age of 5, and over the years discovered how diet could be used to alleviate my symptoms. While I am pretty diet agnostic, I have found ways that work for me, and love to help people discover ways they can do the same! I also own a small business called Alacrity Nutrition, which seeks to help people discover what gets them excited about health. Check out my website at:

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