Love Thy Brain

Love Thy Brain

In today's world, brimming with distractions, substances that can cause harm (whether through food or... other forms of fun), and environments that often reward poor habits, the importance of protecting, respecting, and loving our brains has never been more critical. Yes, indulging in a bit of social media, enjoying our favorite pizza and ice cream, savoring a glass of whiskey, or partying with friends occasionally is perfectly fine. However, it's crucial to remember that excessive indulgence in these types of activities can be detrimental.


Fortunately, there are countless ways to derive pleasure that don't involve excessive or potentially harmful habits.

Showing love to our brain can manifest in various forms, such as engaging in fulfilling social interactions, consuming nutritionally sound meals, utilizing supplementation when appropriate, playing outside in the dirt, practicing meditation, exploring creative outlets, and enjoying the company of fluffy animal companions.

The possibilities for contributing to our brain health are vast and varied, making it almost impossible to list them all. In this discussion, we'll explore some key strategies that can help us nurture and cherish our brains, ensuring they receive the love and care they deserve!


Endogenous Chemicals Associated With Brain Health And Happiness

Before we dive into how different activities and supplements can benefit us, it's crucial to get a quick understanding of how some of these chemicals play a pivotal role in our happiness and longevity. These neurotransmitters, peptides, endocannabinoids, and hormones are responsible for some of the good feelings we experience and contribute significantly to our ability to lead longer, healthier lives. While we'll explore some of these chemicals briefly below, keep in mind that this list isn't exhaustive. However, it's always beneficial to have a basic understanding of the elements that enhance our well-being and push us towards a more fulfilled existence!



Often referred to as the "feel-good" neurotransmitter, dopamine is associated with pleasure, reward, and motivation. It is released when we engage in activities that are perceived as rewarding, encouraging us to repeat these actions.



Serotonin contributes to feelings of happiness and well-being. It helps regulate mood, anxiety, and happiness. Low levels of serotonin are associated with depression and anxiety disorders.



Known as the "love hormone," oxytocin is released during physical touch and social bonding (e.g., hugging, childbirth, and intimacy). It promotes feelings of love, social bonding, and trust, reducing stress and anxiety.



Endorphins are the body's natural painkillers, produced in response to stress and physical discomfort (e.g., during exercise, known as the "runner's high"). They help alleviate pain and induce feelings of euphoria and well-being.



Sometimes referred to as the "bliss molecule," anandamide is a cannabinoid neurotransmitter that binds to the same receptors as THC (the active compound in cannabis). It plays a role in mood regulation, brain function, and feelings of happiness and can alleviate anxiety and depression.


GABA (Gamma-Aminobutyric Acid)

GABA is an inhibitory neurotransmitter that reduces neuronal excitability throughout the nervous system. It helps promote relaxation and reduces stress levels, contributing to a sense of calm and well-being.


Norepinephrine (Noradrenaline)

Norepinephrine acts as both a hormone and a neurotransmitter and is involved in the body's "fight or flight" response. It increases arousal and alertness, improves focus, and can enhance mood by promoting energy and optimism.


Brain-Derived Neurotrophic Factor (BDNF)

BDNF supports the survival of existing neurons and encourages the growth and differentiation of new neurons and synapses. It is crucial for learning, memory, and higher thinking. BDNF also plays a protective role against neurodegeneration.


Glial Cell Line-Derived Neurotrophic Factor (GDNF)

GDNF promotes the survival of many types of neurons, including dopaminergic neurons, which are crucial for movement and have been implicated in conditions like Parkinson's disease. It helps protect against neural damage.


Nerve Growth Factor (NGF)

NGF is essential for the growth, maintenance, and survival of certain neurons. It helps guide neurons to targets and stimulates neural growth. NGF also plays a role in repairing neurons and can enhance cognitive functions.


Neurotrophin-3 (NT-3)

NT-3 supports the survival and differentiation of neurons in the peripheral and central nervous systems. It's important for the development and function of the nervous system and plays a role in neuroplasticity.



Antioxidants neutralize harmful free radicals in the brain, protecting neurons from oxidative stress and damage, which is linked to neurodegenerative diseases like Alzheimer's and Parkinson's disease. Endogenous examples of these would be glutathione (GSH) and superoxide dismutase (SOD).


Endocannabinoids (e.g., Anandamide)

Endocannabinoids are naturally produced compounds that bind to cannabinoid receptors in the brain. They regulate several cognitive and physiological processes, including mood, memory, appetite, and pain sensation, and provide neuroprotective effects.


Insulin-like Growth Factor 1 (IGF-1)

IGF-1 is a hormone similar in structure to insulin and plays a crucial role in brain development and plasticity. It promotes neuronal growth, survival, and differentiation and has been shown to improve cognitive performance in some settings.


Brain Health And Exercise

When I think about brain and mental health, my thoughts immediately gravitate towards exercise and movement. The beauty of movement lies in its accessibility; it can be entirely free or at the very least, incredibly affordable. Additionally, the variety it offers is vast—so if running or weight lifting doesn't appeal to you, there's a whole world of alternatives like yoga, rock climbing, surfing, team sports, or even something as primal as chopping wood! Granted, this list barely scratches the surface of the endless options available, and attempting to catalogue every form of exercise would make this discussion unnecessarily lengthy. The key takeaway is the importance of staying active. Engaging in physical activity generates a cascade of beneficial endogenous chemicals (think dopamine, endorphins, and even serotonin) that not only boost our mood but also fortify our brains against the ravages of time. Indeed, regular exercise is a potent ally in the fight against age-related cognitive decline and neurodegeneration, offering a natural, drug-free path to maintaining our mental acuity.

Diving deeper into the beneficial impact of exercise on our brain, let's explore what scientific research has uncovered. For those who've been following our content, you're probably already well acquainted with BDNF, that incredible little neurotrophic factor. BDNF is pivotal for the survival and growth of neurons, acts as a modulator of neurotransmitters, and plays a key role in neural plasticity, which is essential for learning and memory. When we examine the monoamine systems—encompassing dopamine, noradrenaline, and serotonin—a substantial body of evidence suggests that exercise enhances various brain functions through these channels.

The stimulation of these systems, and consequently the production of these neurotransmitters, is influenced by the intensity of the exercise. Yet, even moderate activity can create positive effects. Increased dopamine levels stimulate our reward center, fostering motivation. Serotonin helps regulate our mood, instilling a sense of calm, balance, and happiness. Norepinephrine sharpens our alertness and attention. Moreover, exercise prompts the release of endogenous opioid peptides, commonly known as endorphins. These endorphins further boost the release of dopamine and serotonin, enhancing the overall sense of well-being. This intricate interplay of chemicals not only enriches our mental health, but underscores the profound connection between physical activity and cognitive function. Another thing to note, is that exercise stimulates the production of insulin-like growth factor-1 (IGF-1), which in the context of brain health, stimulates neurogenesis, has neuroprotective effects, may enhance cognitive function, helps regulate our brains protective barrier (the blood brain barrier), and has anti-inflammatory effects.


Brain Health And Supplementation

Dietary supplements have risen as effective tools, providing a variety of nutrients known to bolster the brain against age-related decline and boost cognitive functions. Some of the more well known in this arsenal are omega-3 fatty acids, antioxidants, and B vitamins, each heralded for their profound neuroprotective properties. Omega-3s, especially DHA and EPA, are vital for the preservation of brain cell membrane integrity, the enhancement of neuroplasticity, and anti-inflammatory benefits that protect against cognitive decline. Antioxidants, tackle oxidative stress—a prominent culprit in the onset of neurodegenerative diseases such as Alzheimer's and Parkinson's—by neutralizing destructive free radicals. Meanwhile, B vitamins, namely methylated B vitamins, are instrumental in lowering homocysteine levels, which, when elevated, are linked to cognitive deficits and an increased risk of brain atrophy.

Looking further into the realm of cognitive enhancement and neuroprotection, an extensive array of supplements has garnered attention for their promising brain health advantages. These have been recently dubbed the name of “nootropics.” Noteworthy among these are Ginkgo biloba, Alpha GPC, L-Tyrosine, L-Theanine, and Lion's Mane mushroom, each emerging as a contender for enhancing brain function. Ginkgo biloba, celebrated for its capacity to foster circulation and cognitive function, is a favored pick for those aiming to sharpen memory and focus. Alpha GPC, a choline derivative, champions brain health by promoting the production of acetylcholine, a neurotransmitter pivotal for memory and learning. L-Tyrosine, an amino acid, acts as a building block for neurotransmitters like dopamine and norepinephrine, crucial for maintaining cognitive alertness and emotional balance. L-Theanine, a compound found in green tea and even black tea, induces relaxation without sedation, bolstering attention span while alleviating stress. Lastly, Lion's Mane mushroom is renowned for its ability to trigger nerve growth factor production, supporting neuronal development and offering a shield against cognitive decline.

An important thing to note about supplementation is that their uses can be highly individual and provide different results depending on your current status. For instance, someone that is already high dopamine taking l-tyrosine may feel a bit overstimulated, while someone that is lower in dopamine may feel profound benefits. It is best to consult with a professional in the space to properly navigate this piece. Supplements albeit effective, can be very confusing, especially if we are just taking them simply because we heard, “take this because it’s good for you.” We should have an understanding of WHY we are taking these things prior to taking them.


Social Connections And Longevity

Social connections offer far more than mere enjoyment with our loved ones—and yes, this extends to our furry friends. These connections imbue our lives with purpose and satisfaction, acting as a bulwark against the likes of depression and social anxiety, with their positive effects rippling throughout our lifespan. Intriguingly, Holt-Lunstad's meta-analysis, which examined data from over 308,000 individuals, reveals that people entrenched in poor-quality relationships face a twofold increase in the risk of premature death. This statistic startlingly surpasses the risk associated with smoking a pack of cigarettes daily. Relationships, through their intricate web, bolster our mental health by modulating our responses to life's stresses. This enhancement is partly attributed to elevated levels of "happiness chemicals" such as dopamine, serotonin, and oxytocin, and is also seen in the reduction of blood pressure, likely a byproduct of these chemical releases. High-quality social interactions serve as pillars for various essential aspects of our existence, including motivation, reward, identity, and sensory processing, affirming that even brief but meaningful exchanges can cause significant benefits.

Turning our attention to the animal kingdom, the companionship of pets mirrors some of these human-centric benefits. Studies have demonstrated that interactions with animals can lead to reduced cortisol levels and lower blood pressure, with pet engagement notably boosting oxytocin levels. Pets carve out a unique niche in our social/emotional ecosystem, offering us a sense of purpose, trust, and loyalty akin to human relationships but without the complexity of human interactions. The simplicity and purity of the bond with our pets underscores the diverse nature of social connections in enriching our lives, highlighting that sometimes, the most straightforward interactions can be the most rewarding.


The Benefits Of Being Outside

Although direct research on nature's impact on our brains and overall health is somewhat scarce at the moment, there's compelling evidence from cross-sectional observational studies linking exposure to nature with a host of benefits. These studies have highlighted how getting outside is not only associated with increased physical activity but also with reductions in cardiovascular disease. Meanwhile, longitudinal observational studies are starting to peel back the layers on nature's potential long-term benefits, investigating its effects on depression, anxiety, cognitive function, and various chronic diseases.


Diving deeper, there's an additional layer of benefit that's particularly exciting. A comprehensive brain analysis revealed that spending time outdoors is positively linked with an increase in grey matter volume in the right dorsolateral prefrontal cortex. This is big news because grey matter is the stuff in our brains responsible for motor skills, memory and emotions. Essentially, an uptick in grey matter volume in this brain region could enhance processing capabilities and foster further mental development. So, in essence, soaking up some nature could be akin to giving your brain a bit of a workout, with all the added benefits of fostering emotional well-being and cognitive health.



Recent research is exploring into the effects of mindfulness meditation on the brain, suggesting its potential to induce long-term changes in the brain's network structure. A study, focusing on seasoned Vipassana meditators, utilized an analysis on magnetoencephalography (MEG) data to compare brain connectivity patterns during rest with those of non-meditating controls. While initial results showed no significant global network differences, a deeper analysis showed that, after statistical adjustments, the right hippocampus in meditators exhibited enhanced connectivity in the theta frequency band compared to controls. Theta states occur while we are in connection with creative practices, daydreaming, and fantasizing, and is a repository for memories and emotions. This finding suggests a more pronounced role of the right hippocampus in the brain's network among meditators, hinting at the deep-rooted impact of meditation on brain connectivity, particularly in areas associated with memory and spatial processing.

The study's insights into the right hippocampus—which highlights its involvement in memory and visuo-spatial processing—underscore the potential of mindfulness meditation as a non-pharmacological intervention for enhancing cognitive functions and brain health. This increase in theta band connectivity in meditators aligns with the hippocampus's key roles in memory and orientation, supporting the idea that meditation could specifically benefit prospective and spatial memory. Additionally, the distinction between the functional roles of the right and left hippocampus, with the right side being more involved in the visualization of future events, aligns with the meditation-induced enhancements in theta power, crucial for episodic memory and orientation in time and space.

When it comes to brain health, we have quite an arsenal of tools without our reach. Movement, supplementation, social connections, playing with the trees, and various meditations practices can help us maintain and even strengthen our brain and mind. It has become increasingly more important to maintain our brain health in this time due to the current barrage of influences that reward poor habits, so picking up even just a few of these could really go a long way. Our brain does SO much for us, so it deserves to be treated with love and respect. Love thy brain!





Meet the Author:
David Battisti, MScN

I am a multi-sport athlete with a fascination with nutritional sciences. I was diagnosed with severe chronic asthma at the age of 5, and over the years discovered how diet could be used to alleviate my symptoms. While I am pretty diet agnostic, I have found ways that work for me, and love to help people discover ways they can do the same! I also own a small business called Alacrity Nutrition, which seeks to help people discover what gets them excited about health. Check out my website at:

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